SCHEMBL8106637

SCHEMBL8106637

CCOc1ccc(N2CCNCC2)cc1OC

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 3/20 0.52
CHRNA4 P43681 3/20 0.52
ADRB1 P08588 4/20 0.51
HTR3E A5X5Y0 2/20 0.51
HTR3B O95264 2/20 0.51
HTR3A P46098 2/20 0.51
HTR3D Q70Z44 2/20 0.51
HTR3C Q8WXA8 2/20 0.51
SIGMAR1 Q99720 1/20 0.51
HTR1A P08908 2/20 0.51
HTR7 P34969 2/20 0.51
HTR1D P28221 1/20 0.50
HTR1B P28222 1/20 0.50
TGFBR1 P36897 1/20 0.49
ACVR1 Q04771 1/20 0.49
TLR9 Q9NR96 1/20 0.48
TLR8 Q9NR97 1/20 0.48
TLR7 Q9NYK1 1/20 0.48
SMN1; SMN2 Q16637 1/20 0.48
ALK Q9UM73 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL361649 0.88 ADRB1 (0.61) CHRNB2CHRNA4ADRB1HTR3EHTR3B
Hydrochloric Acid SCHEMBL2156292 0.86 ADRB1 (0.59) CHRNB2CHRNA4ADRB1HTR3EHTR3B
Hydrochloric Acid SCHEMBL7711565 0.86 ADRB1 (0.59) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL14922727 0.86 CHRNB2 (0.52) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL8112635 0.82 TLR9 (0.48) TLR9TLR8TLR7SMN1; SMN2KDM4E
SCHEMBL1599427 0.82 CHRNB2 (0.49) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL11295851 0.82 CHRNB2 (0.52) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL2876111 0.82 ADRB1 (0.59) CHRNB2CHRNA4ADRB1HTR3EHTR3B
SCHEMBL19709332 0.81 CHRNB2 (0.53) CHRNB2CHRNA4ADRB1HTR3EHTR3B
Hydrochloric Acid SCHEMBL1639434 0.81 ADRB1 (0.58) CHRNB2CHRNA4ADRB1HTR3EHTR3B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009001127-A1 CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS ASTRAZENECA AB (SE) 2008-12-31 WO disclosed