Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19867672 | 0.96 | KMT2A (0.38) | HPGDEPHX1KMT2AHSD11B1TDP1 | |
| SCHEMBL3846912 | 0.89 | HPGD (0.47) | HPGDEPHX1KMT2AHSD11B1TDP1 | |
| SCHEMBL6662692 | 0.89 | HPGD (0.47) | HPGDEPHX1KMT2AHSD11B1TDP1 | |
| SCHEMBL327378 | 0.87 | KMT2A (0.43) | HPGDEPHX1KMT2AHSD11B1TDP1 | |
| SCHEMBL8535268 | 0.83 | HPGD (0.42) | HPGDEPHX1KMT2AHSD11B1TDP1 | |
| SCHEMBL14751461 | 0.82 | — | — | |
| SCHEMBL787945 | 0.82 | CYP1A2 (0.48) | HPGDEPHX1KMT2AEPHX2CYP1A2 | |
| SCHEMBL1916162 | 0.81 | LMNA (0.53) | HPGDEPHX1KMT2AEPHX2LMNA | |
| SCHEMBL11652994 | 0.81 | HPGD (0.50) | HPGDKMT2AHSD11B1CYP1A2NPC1 | |
| SCHEMBL909693 | 0.80 | EPHX1 (0.42) | HPGDEPHX1KMT2AHSD11B1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008150486-A2 | 2-ACYLAMINOPROPOANOL-TYPE GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | GENZYME CORPORATION (US) | 2008-12-11 | — | — | WO | disclosed |