Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 6/20 | 0.70 |
| ▸ | CYSLTR1 | Q9Y271 | 6/20 | 0.70 |
| ▸ | RAB9A | P51151 | 8/20 | 0.70 |
| ▸ | NPC1 | O15118 | 7/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.70 |
| ▸ | LMNA | P02545 | 3/20 | 0.70 |
| ▸ | PKM | P14618 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | GLA | P06280 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | ECE2 | P0DPD6 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8107518 | 1.00 | CYSLTR2 (0.70) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL6759175 | 0.83 | RAB9A (0.74) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL8303664 | 0.83 | CYSLTR1 (0.55) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL8303662 | 0.83 | CYSLTR1 (0.55) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL12884278 | 0.83 | RAB9A (0.73) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL659665 | 0.83 | RAB9A (1.00) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL30708719 | 0.83 | RAB9A (1.00) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL659666 | 0.83 | RAB9A (1.00) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL6796716 | 0.83 | CYSLTR2 (0.68) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E | |
| SCHEMBL6796712 | 0.83 | CYSLTR2 (0.68) | CYSLTR2CYSLTR1RAB9ANPC1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6121286-A | ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, FOR TREATING ASTHMA; COMPOUNDS SUCH AS 6-METHOXY-3-(2-(3-(2-QUINOLYLMETHOXY)BENZYL)TETRAZOLYL)QUINOLIN-2-ONE | KOWA CO., LTD. (JP) | 2000-09-19 | — | — | US | disclosed |
| US-6117886-A | EXCELLENT ANTILEUKOTRIENE ACTIVITY AND ANTIHISTAMINIC ACTIVITY, AND IS USEFUL FOR THE PREVENTION AND TREATMENT OF, FOR EXAMPLE, ASTHMA. | KOWA CO., LTD. (JP) | 2000-09-12 | — | — | US | disclosed |
| EP-0469833-B1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY CO ELI (GB) | 1999-09-08 | — | — | EP | disclosed |
| CN-1040108-C | Pharmaceutical compounds | LILLY INDUSTRIES LTD (GB) | 1998-10-07 | — | — | CN | disclosed |
| CN-1061413-A | Medicinal compound | LILLY INDUSTRIES LTD (GB) | 1992-05-27 | — | — | CN | disclosed |
| EP-0469833-A1 | N-Benzyl-Indoles, processes for their preparation and pharmaceutical compositions containing them | LILLY INDUSTRIES LIMITED (GB) | 1992-02-05 | — | — | EP | disclosed |