Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.54 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.54 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.54 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 1/20 | 0.53 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10690654 | 0.88 | KMT2A (0.59) | ALDH1A1MEN1KMT2AADRB2PLAAT3 | |
| SCHEMBL742343 | 0.83 | KMT2A (0.71) | ALDH1A1MEN1KMT2AADRB2PLAAT3 | |
| SCHEMBL8098635 | 0.82 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2AADRB2PLAAT3 | |
| SCHEMBL6094268 | 0.82 | ALDH1A1 (0.62) | ALDH1A1MEN1KMT2AADRB2PLAAT3 | |
| SCHEMBL11509318 | 0.81 | ALDH1A1 (0.61) | HTTALDH1A1MEN1KMT2AADRB2 | |
| SCHEMBL8428854 | 0.81 | ALDH1A1 (0.61) | ALDH1A1MEN1KMT2AADRB2PLAAT3 | |
| SCHEMBL20418416 | 0.81 | ALDH1A1 (0.61) | HTTALDH1A1MEN1KMT2AADRB2 | |
| SCHEMBL6376353 | 0.81 | POLB (0.68) | ALDH1A1MEN1KMT2AADRB2PLAAT3 | |
| SCHEMBL2778736 | 0.78 | ALDH1A1 (0.57) | ALDH1A1MEN1KMT2AADRB2PLAAT3 | |
| SCHEMBL11888467 | 0.77 | GAA (0.65) | ALDH1A1MEN1KMT2AMAPTCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136819-A | COMPOUNDS FOR ANTIINFLAMMATORY AGENTS OR CARDIOVASCULAR DISORDERS | BOEHRINGER INGELHEIM GMBH (DE) | 2000-10-24 | — | — | US | disclosed |
| US-5968948-A | FOR TREATMENT OF EPILEPSY, STROKE, ALZHEIMER'S DISEASE, BRAIN DISEASES OR AS ANTIINFLAMMATORY OR ANTIPROLIFERATIVE AGENTS | BOERHINGER INGELHEIM GMBH (DE) | 1999-10-19 | — | — | US | disclosed |
| US-5661157-A | Annelated dihydropyridines and the use thereof for preparing pharmaceutical preparations | BOEHRINGER INGELHEIM KG (DE) | 1997-08-26 | — | — | US | disclosed |