Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.64 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.60 |
| ▸ | CA12 | O43570 | 1/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.60 |
| ▸ | CA9 | Q16790 | 1/20 | 0.60 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.60 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.60 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.60 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8098635 | 0.89 | ALDH1A1 (0.62) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL6094268 | 0.89 | ALDH1A1 (0.62) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL20418416 | 0.88 | ALDH1A1 (0.61) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL8428854 | 0.88 | ALDH1A1 (0.61) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL11509318 | 0.88 | ALDH1A1 (0.61) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL6376353 | 0.86 | POLB (0.68) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL10690654 | 0.84 | KMT2A (0.59) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL8107748 | 0.83 | HTT (0.57) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL2778736 | 0.83 | ALDH1A1 (0.57) | KMT2AMEN1ALDH1A1ADRB2CA12 | |
| SCHEMBL8428857 | 0.83 | ALDH1A1 (0.56) | KMT2AMEN1ALDH1A1ADRB2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3079680-A2 | COMPOSITIONS AND METHODS FOR TREATING, PREVENTING AND DIAGNOSING CANCER AND OTHER PROLIFERATIVE DISORDERS | Angiogenex, Inc. (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015089495-A2 | COMPOSITIONS AND METHODS FOR TREATING, PREVENTING AND DIAGNOSING CANCER AND OTHER PROLIFERATIVE DISORDERS | ANGIOGENEX, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| US-8138356-B2 | Chemical inhibitors of inhibitors of differentiation | Angiogeney, Inc. (US) | 2012-03-20 | — | — | US | disclosed |
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | ANGIOGENEX | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090226422-A1 | Chemical Inhibitors of Inhibitors of Differentiation | BRAF, MAPK1, RAF1 | KMT2A 3273/4885MEN1 3968/4885ALDH1A1 1860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.