Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CPA3 | P15088 | 1/20 | 0.48 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL991988 | 1.00 | RIPK1 (0.52) | RIPK1LMNAALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL258372 | 1.00 | RIPK1 (0.52) | RIPK1LMNAALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL8742857 | 0.89 | HDAC3 (0.50) | RIPK1LMNAALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL2743315 | 0.89 | HDAC3 (0.50) | RIPK1LMNAALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL7345068 | 0.88 | FFAR1 (0.52) | LMNAALDH1A1CYP1A2CYP2D6TSHR | |
| SCHEMBL27820361 | 0.88 | TBXAS1 (0.55) | RIPK1LMNAALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL27585172 | 0.88 | TBXAS1 (0.55) | RIPK1LMNAALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL9308449 | 0.86 | TBXAS1 (0.58) | RIPK1SMN1; SMN2MAPK1 | |
| SCHEMBL6907990 | 0.86 | TBXAS1 (0.58) | RIPK1SMN1; SMN2MAPK1 | |
| SCHEMBL6907995 | 0.86 | TBXAS1 (0.58) | RIPK1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6028224-A | Fluoxetine process from benzoylpropionic acid | SEPRACOR INC. (US) | 2000-02-22 | — | — | US | claimed |
| WO-1999067196-A1 | FLUOXETINE PROCESS FROM BENZOYLPROPIONIC ACID | SEPRACOR INC. (US) | 1999-12-29 | — | — | WO | claimed |
| US-5936124-A | Fluoxetine process from benzoylpropionic acid | SEPACOR INC. (US) | 1999-08-10 | — | — | US | claimed |
| CN-101701227-B | Method for preparing optically pure 2-hydroxy-4-phenyl butyric acid with lactonase | UNIV EAST CHINA SCIENCE & TECH | 2012-01-11 | — | — | CN | disclosed |
| CN-101701227-A | Method for preparing optically pure 2-hydroxy-4-phenyl butyric acid with lactonase | UNIV EAST CHINA SCIENCE & TECH | 2010-05-05 | — | — | CN | disclosed |
| CN-100480249-C | Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors | PROSIDION LTD (GB) | 2009-04-22 | — | — | CN | disclosed |
| CN-1826340-A | Pyrrolopyridine-2-carboxylic acid amides as glycogen phosphorylase inhibitors | PROSIDION LTD (GB) | 2006-08-30 | — | — | CN | disclosed |