SCHEMBL8108301

SCHEMBL8108301

O=C(CO)c1cccc(NC(=O)c2ccc(OCCCc3ccccc3)cc2)c1

nearest known ligand 0.78

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
NR1H4 Q96RI1 13/20 0.78
MEN1 O00255 5/20 0.55
KMT2A Q03164 5/20 0.55
NPC1 O15118 4/20 0.55
RAB9A P51151 3/20 0.52
POLB P06746 1/20 0.52
SENP8 Q96LD8 1/20 0.52
SENP7 Q9BQF6 1/20 0.52
SENP6 Q9GZR1 1/20 0.52
KCNK9 Q9NPC2 1/20 0.51
SMN1; SMN2 Q16637 1/20 0.51
MAPT P10636 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8119505 0.97 NR1H4 (0.83) NR1H4MEN1KMT2ANPC1RAB9A
SCHEMBL6165569 0.97 NR1H4 (0.83) NR1H4MEN1KMT2ANPC1RAB9A
SCHEMBL6577552 0.96 NR1H4 (0.82) NR1H4MEN1KMT2ANPC1RAB9A
SCHEMBL6581896 0.94 NR1H4 (0.72) NR1H4MEN1KMT2ANPC1RAB9A
SCHEMBL6577802 0.88 NR1H4 (0.62) NR1H4MEN1KMT2ARAB9APOLB
SCHEMBL6577998 0.88 NR1H4 (0.65) NR1H4MEN1KMT2ARAB9APOLB
SCHEMBL6577743 0.87 NR1H4 (0.80) NR1H4MEN1KMT2ANPC1RAB9A
SCHEMBL6577705 0.86 NR1H4 (0.78) NR1H4MEN1KMT2ANPC1RAB9A
SCHEMBL6580077 0.84 NR1H4 (0.70) NR1H4MEN1KMT2ANPC1RAB9A
SCHEMBL22192243 0.83 NR1H4 (0.71) NR1H4MEN1KMT2ANPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0634409-B1 Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL CO (JP) 2000-04-26 EP disclosed
US-5659051-A Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1997-08-19 US disclosed
EP-0634409-A1 Process of producing 2-cyano-4-oxo-4H-benzopyran compounds SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1995-01-18 EP disclosed