Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNMT | P11086 | 9/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 7/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3706148 | 0.73 | PNMT (0.55) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL7462280 | 0.69 | PNMT (0.40) | PNMTADRA2AADRA2BADRA2CHTT | |
| SCHEMBL27492215 | 0.68 | PNMT (0.68) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL7462285 | 0.67 | ALDH1A1 (0.43) | PNMTADRA2AADRA2BADRA2CHTT | |
| SCHEMBL7466993 | 0.66 | PNMT (0.46) | PNMTADRA2AADRA2BADRA2CTDP1 | |
| SCHEMBL2728205 | 0.65 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL29370265 | 0.65 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL4551781 | 0.65 | PNMT (0.57) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL1640125 | 0.65 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C | |
| SCHEMBL30561524 | 0.65 | PNMT (0.56) | PNMTADRA2AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6136826-A | AMINOPIPERIDINE COMPOUNDS SUBSTITUTED WITH ALKANOYL | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2000-10-24 | — | — | US | disclosed |