Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4703106 | 1.00 | ALDH1A1 (0.61) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL9830941 | 0.89 | ALDH1A1 (0.57) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL11356824 | 0.83 | LMNA (0.83) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL7989530 | 0.83 | LMNA (0.83) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL1045922 | 0.83 | LMNA (0.83) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL7989269 | 0.83 | LMNA (0.83) | ALDH1A1LMNAPOLBMEN1KMT2A | |
| SCHEMBL941871 | 0.82 | KDM4E (0.62) | ALDH1A1MEN1KMT2AKDM4EHRH3 | |
| SCHEMBL12625982 | 0.81 | ALDH1A1 (0.59) | ALDH1A1POLBMEN1KMT2AHRH3 | |
| SCHEMBL758418 | 0.81 | HRH3 (0.50) | HRH3 | |
| SCHEMBL4591888 | 0.81 | ALDH1A1 (0.59) | ALDH1A1LMNAPOLBKDM4EHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056744-A1 | 6,9-DISUBSTITUTED 2- TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | Aventis Pharmaceuticals Inc. (US) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999043675-A1 | 6,9-DISUBSTITUTED 2-[TRANS-(4- AMINOCYCLOHEXYL) AMINO]PURINES | AVENTIS PHARMACEUTICALS INC. (US) | 1999-09-02 | — | — | WO | disclosed |