Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.38 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.38 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.38 |
| ▸ | HTR3A known ✓ | P46098 | 1/20 | 0.38 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | SPNS2 | Q8IVW8 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8100497 | 0.95 | MAPT (0.72) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL8114174 | 0.94 | MAPT (0.74) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL7302713 | 0.89 | MAPT (0.66) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL9815929 | 0.81 | MAPT (0.97) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL1640658 | 0.80 | MAPT (0.66) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL10353474 | 0.80 | MAPT (0.80) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| Bromide SCHEMBL8110043 | 0.79 | HRH3 (0.63) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| Bromide SCHEMBL8100697 | 0.78 | HRH3 (0.62) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL9687084 | 0.78 | MAPT (0.50) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL3452908 | 0.78 | LMNA (0.80) | MAPTLMNAMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0751132-B1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO (JP) | 2000-08-30 | — | — | EP | disclosed |
| EP-0751132-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1997-01-02 | — | — | EP | disclosed |