Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 3/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.41 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL8108897 | 0.78 | MAPT (0.69) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL8114174 | 0.78 | MAPT (0.74) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| Bromide SCHEMBL8100497 | 0.77 | MAPT (0.72) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL3452908 | 0.74 | LMNA (0.80) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL3095902 | 0.74 | LMNA (0.64) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| Bromide SCHEMBL8110043 | 0.73 | HRH3 (0.63) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL8791883 | 0.73 | HRH3 (0.63) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL7302713 | 0.73 | MAPT (0.66) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| Bromide SCHEMBL8100697 | 0.72 | HRH3 (0.62) | MAPTLMNAMEN1KMT2ACYP1A2 | |
| SCHEMBL1392640 | 0.70 | LMNA (0.67) | MAPTLMNAMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |