Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KHK | P50053 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.44 |
| ▸ | KIF11 | P52732 | 2/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.41 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.41 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL315161 | 0.83 | ADRB1 (0.63) | KHKMAPTADRB1 | |
| SCHEMBL30208090 | 0.81 | HTR3E (0.61) | KHKMAPTADRB1BCL2A1 | |
| SCHEMBL12892626 | 0.81 | HTR3E (0.61) | KHKMAPTADRB1BCL2A1 | |
| SCHEMBL2245201 | 0.81 | HTR3E (0.61) | KHKMAPTADRB1BCL2A1 | |
| SCHEMBL4240000 | 0.81 | HTR3E (0.61) | KHKMAPTADRB1BCL2A1 | |
| SCHEMBL24028605 | 0.80 | MAPT (0.46) | KHKMEN1KMT2AMAPTADRB1 | |
| SCHEMBL22411504 | 0.80 | MAPT (0.46) | KHKMEN1KMT2AMAPTADRB1 | |
| SCHEMBL2873025 | 0.80 | ADRB1 (0.65) | KHKDRD2MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL20139242 | 0.80 | HTR3E (0.59) | KHKMAPTADRB1BCL2A1 | |
| SCHEMBL15579346 | 0.80 | HTR7 (0.62) | KHKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |