Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.49 |
| ▸ | XIAP | P98170 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | BCL2A1 | Q16548 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4513999 | 0.82 | KDR (0.48) | ADRA2AADRA1DADRA1AADRA1BADRA2C | |
| SCHEMBL5631645 | 0.80 | XIAP (0.45) | HSD11B1XIAPALDH1A1LMNAHTR2C | |
| SCHEMBL5631643 | 0.80 | XIAP (0.45) | HSD11B1XIAPALDH1A1LMNAHTR2C | |
| SCHEMBL8110545 | 0.79 | HSD11B1 (0.47) | HSD11B1ALDH1A1LMNAMAPTBCL2A1 | |
| SCHEMBL14922244 | 0.77 | ALDH1A1 (0.48) | HSD11B1XIAPALDH1A1LMNAHTR2C | |
| SCHEMBL2595341 | 0.76 | ALDH1A1 (0.48) | HSD11B1XIAPALDH1A1LMNAHTR2C | |
| SCHEMBL2595344 | 0.76 | ALDH1A1 (0.48) | HSD11B1XIAPALDH1A1LMNAHTR2C | |
| SCHEMBL21358963 | 0.76 | LMNA (0.47) | HSD11B1XIAPALDH1A1LMNAHTR2C | |
| SCHEMBL21358964 | 0.76 | LMNA (0.47) | HSD11B1XIAPALDH1A1LMNAHTR2C | |
| SCHEMBL21358968 | 0.76 | LMNA (0.47) | HSD11B1XIAPALDH1A1LMNAHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009001127-A1 | CYANOCYCLOPROPYLCARBOXAMIDES AS CATHEPSIN INHIBITORS | ASTRAZENECA AB (SE) | 2008-12-31 | — | — | WO | disclosed |