Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY1R | P25929 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 5/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | LITAF | Q99732 | 2/20 | 0.34 |
| ▸ | HTR2A | P28223 | 2/20 | 0.34 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2660594 | 0.91 | NPY1R (0.38) | NPY1RNPY5RHTR2BHRH3KCNH2 | |
| SCHEMBL2669423 | 0.91 | GABRG2 (0.43) | NPY1RNPY5RHTR2BHRH3KCNH2 | |
| SCHEMBL4916106 | 0.90 | NPY1R (0.42) | NPY1RNPY5RHTR2BHRH3KCNH2 | |
| SCHEMBL2669426 | 0.90 | NPY1R (0.40) | NPY1RNPY5RHTR2BHRH3KCNH2 | |
| SCHEMBL2660932 | 0.89 | GABRA1 (0.43) | NPY1RNPY5RHTR2BLMNATP53 | |
| SCHEMBL4921068 | 0.89 | NPY1R (0.39) | NPY1RNPY5RHTR2BHRH3KCNH2 | |
| SCHEMBL2661378 | 0.88 | DPP4 (0.39) | NPY1RNPY5RHRH3KCNH2LMNA | |
| SCHEMBL2661690 | 0.87 | GABRA1 (0.44) | NPY1RNPY5RHTR2BHTR2AGABRG2 | |
| SCHEMBL2661319 | 0.87 | NPY1R (0.39) | NPY1RNPY5RHTR2BTP53MAPT | |
| SCHEMBL4922297 | 0.86 | NPY1R (0.43) | NPY1RNPY5RLMNATP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008155572-A2 | FUSED QUINOLINE DERIVATIVES USEFUL AS GABA MODULATORS | ASTRAZENECA AB (SE) | 2008-12-24 | — | — | WO | disclosed |