SCHEMBL8109600

SCHEMBL8109600

O=C(O)c1cccc2c(-c3ccncc3)cccc12

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HNF4A P41235 1/20 0.49
NR4A1 P22736 1/20 0.48
NR4A2 P43354 1/20 0.48
NR4A3 Q92570 1/20 0.48
DHODH Q02127 1/20 0.48
ALDH1A1 P00352 2/20 0.47
PIK3CD O00329 1/20 0.45
KDM4E B2RXH2 2/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
KDM4A O75164 1/20 0.44
RAB9A P51151 1/20 0.44
EGLN1 Q9GZT9 1/20 0.44
HIF1AN Q9NWT6 1/20 0.44
TYMS P04818 1/20 0.44
HSD17B10 Q99714 2/20 0.43
MCL1 Q07820 1/20 0.43
ACMSD Q8TDX5 1/20 0.43
TNF P01375 1/20 0.42
HPGD P15428 1/20 0.42
SMN1; SMN2 Q16637 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29105027 0.86 ALDH1A1 (0.49) HNF4ANR4A1NR4A2NR4A3DHODH
SCHEMBL8890007 0.85 HNF4A (0.66) HNF4ANR4A1NR4A2NR4A3ALDH1A1
SCHEMBL6794827 0.83 ALDH1A1 (0.60) HNF4ADHODHALDH1A1KDM4EL3MBTL1
SCHEMBL1648889 0.83 DHODH (0.59) HNF4ANR4A1NR4A2NR4A3DHODH
SCHEMBL8108581 0.81 ERN1 (0.48) HNF4ANR4A1NR4A2NR4A3ALDH1A1
SCHEMBL28115051 0.81 IKBKB (0.54) HNF4ADHODHALDH1A1KDM4EL3MBTL1
SCHEMBL1324771 0.80 NR4A1 (0.64) HNF4ANR4A1NR4A2NR4A3ALDH1A1
SCHEMBL30720582 0.80 NR4A1 (0.64) HNF4ANR4A1NR4A2NR4A3ALDH1A1
SCHEMBL26259561 0.80 PIK3CD (0.61) ALDH1A1PIK3CDKDM4ERAB9AHSD17B10
SCHEMBL15567698 0.78 IKBKB (0.48) HNF4AALDH1A1KDM4EL3MBTL1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6159979-A Bicyclic aryl or a bicyclic heterocyclic ring containing compounds having a combined 5HT1A, 5HT1B and 5HT1D receptor antagonistic activity SMITHKLINE BEECHAM P.L.C. (GB) 2000-12-12 US disclosed
CN-1260781-A Indole derivatives having combined 5HT1A, 5HT1B and 5HT1D receptor antagonist activity SMITHKLINE BEECHAM PLC (GB) 2000-07-19 CN disclosed
EP-0975614-A1 A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY SMITHKLINE BEECHAM PLC (GB) 2000-02-02 EP disclosed
EP-0975593-A1 INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 2000-02-02 EP disclosed
WO-1998050358-A1 INDOLE DERIVATIVES HAVING COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONIST ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO disclosed
WO-1998050346-A2 ACETAMIDE AND UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE IN THE TREATMENT OF CNS DISORDERS SMITHKLINE BEECHAM PLC (GB) 1998-11-12 WO disclosed
WO-1998047885-A1 A BICYCLIC ARYL OR A BICYCLIC HETEROCYCLIC RING CONTAINING COMPOUNDS HAVING A COMBINED 5HT1A, 5HT1B AND 5HT1D RECEPTOR ANTAGONISTIC ACTIVITY SMITHKLINE BEECHAM PLC (GB) 1998-10-29 WO disclosed