Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.42 |
| ▸ | GSK3A | P49840 | 2/20 | 0.42 |
| ▸ | GSK3B | P49841 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CCR3 | P51677 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772475 | 0.85 | FAAH (0.42) | FAAHMGLLSIGMAR1GSK3AGSK3B | |
| SCHEMBL8439618 | 0.84 | GSK3A (0.43) | FAAHMGLLSIGMAR1GSK3AGSK3B | |
| SCHEMBL8104210 | 0.82 | MAPT (0.43) | FAAH | |
| SCHEMBL8104122 | 0.82 | MAPT (0.43) | FAAH | |
| SCHEMBL8104172 | 0.81 | EHMT2 (0.44) | MEN1CYP1A2CYP3A4TSHRCYP2C19 | |
| SCHEMBL8102574 | 0.81 | HDAC3 (0.40) | FAAHTDP1MEN1KMT2A | |
| SCHEMBL8772495 | 0.81 | GSK3A (0.41) | SIGMAR1GSK3AGSK3BL3MBTL1MEN1 | |
| SCHEMBL8552234 | 0.80 | PLA2G7 (0.46) | SIGMAR1L3MBTL1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL8104208 | 0.79 | TRPV1 (0.40) | L3MBTL1TSHRKMT2A | |
| SCHEMBL8772509 | 0.79 | TSHR (0.44) | SIGMAR1TDP1L3MBTL1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | claimed |
| EP-0788478-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-13 | — | — | EP | claimed |
| WO-1996013484-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-05-09 | — | — | WO | claimed |
| US-6071899-A | Azetidinone derivatives for the treatment of atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2000-06-06 | — | — | US | disclosed |