Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8772475 | 0.96 | FAAH (0.42) | GSK3AGSK3BSIGMAR1MEN1KMT2A | |
| SCHEMBL8439618 | 0.95 | GSK3A (0.43) | GSK3AGSK3BSIGMAR1MEN1KMT2A | |
| SCHEMBL8772523 | 0.92 | HCRTR1 (0.43) | GSK3AGSK3BGAAHTTMAPK1 | |
| SCHEMBL8619484 | 0.88 | GSK3B (0.39) | GSK3AGSK3BSIGMAR1MEN1KMT2A | |
| SCHEMBL8772402 | 0.88 | HTR2A (0.43) | GSK3AGSK3BSIGMAR1HTR2AGAA | |
| SCHEMBL8772398 | 0.88 | GSK3A (0.39) | GSK3AGSK3BSIGMAR1HTTSMN1; SMN2 | |
| SCHEMBL8555803 | 0.87 | HRH3 (0.41) | SIGMAR1 | |
| SCHEMBL8553771 | 0.85 | TMEM97 (0.44) | SIGMAR1HTR2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL27499799 | 0.85 | TEAD3 (0.40) | GAAMEN1KMT2A | |
| SCHEMBL8553197 | 0.81 | HTR2A (0.40) | SIGMAR1HTR2AKCNH2OPRM1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | claimed |
| WO-1996019451-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1996-06-27 | — | — | WO | claimed |
| EP-0799200-A1 | SUBSTITUTED AZETIDIN-2-ONES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-10-08 | — | — | EP | disclosed |