Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT1 | Q9H9B1 | 4/20 | 0.67 |
| ▸ | EHMT2 | Q96KQ7 | 3/20 | 0.67 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.61 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.61 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.61 |
| ▸ | P2RY1 | P47900 | 4/20 | 0.60 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | P2RY2 | P41231 | 3/20 | 0.60 |
| ▸ | SRC | P12931 | 2/20 | 0.60 |
| ▸ | DPP4 | P27487 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.60 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.60 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.60 |
| ▸ | GAPDH | P04406 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | STAT6 | P42226 | 1/20 | 0.60 |
| ▸ | PI4KA | P42356 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13268990 | 0.87 | EHMT1 (0.71) | EHMT1EHMT2ADORA2AADORA2BADORA3 | |
| SCHEMBL5063589 | 0.85 | ADORA1 (0.65) | EHMT1EHMT2ADORA2AADORA2BADORA3 | |
| SCHEMBL6247323 | 0.84 | AHCY (0.71) | ADORA2AADORA2BADORA3P2RY1ADORA1 | |
| SCHEMBL8164443 | 0.84 | P2RY1 (0.68) | EHMT1ADORA2AADORA2BADORA3P2RY1 | |
| SCHEMBL120562 | 0.84 | ADORA3 (0.68) | EHMT1EHMT2ADORA2AADORA2BADORA3 | |
| SCHEMBL10604277 | 0.83 | EHMT1 (0.76) | EHMT1EHMT2ADORA2AADORA2BADORA3 | |
| SCHEMBL120551 | 0.82 | ADORA3 (0.69) | EHMT1EHMT2ADORA2AADORA2BADORA3 | |
| SCHEMBL3446755 | 0.82 | ADORA1 (0.71) | EHMT1ADORA2AADORA2BADORA3P2RY1 | |
| SCHEMBL3317160 | 0.82 | DOT1L (0.74) | EHMT1EHMT2KMT2ADOT1L | |
| SCHEMBL8007640 | 0.82 | DOT1L (0.65) | ADORA2AADORA2BADORA3P2RY1ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000055-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. Searle & Co. (US) | 2000-05-17 | — | — | EP | disclosed |
| WO-1998052940-A1 | SUBSTITUTED PYRAZOLES AS p38 KINASE INHIBITORS | G.D. SEARLE AND CO. (US) | 1998-11-26 | — | — | WO | disclosed |