Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 3/20 | 0.40 |
| ▸ | BRAF | P15056 | 3/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111019 | 0.85 | FLT3 (0.53) | ALDH1A1RAB9AFLT3GSK3BSMN1; SMN2 | |
| SCHEMBL6310322 | 0.75 | RAB9A (0.50) | ALDH1A1RAB9AFLT3GSK3BSMN1; SMN2 | |
| SCHEMBL8110206 | 0.72 | MAPK13 (0.50) | ALDH1A1GSK3BSMN1; SMN2KMT2ABRAF | |
| SCHEMBL29111820 | 0.70 | PTGS2 (0.52) | ALDH1A1RAB9ASMN1; SMN2KMT2APTGS2 | |
| SCHEMBL7248577 | 0.70 | MAPK14 (0.52) | ALDH1A1RAB9AFLT3GSK3BKMT2A | |
| SCHEMBL31504131 | 0.69 | PTGS2 (0.38) | ALDH1A1RAB9ASMN1; SMN2KMT2APTGS2 | |
| SCHEMBL5829519 | 0.69 | CYP17A1 (0.51) | ALDH1A1RAB9AFLT3GSK3BKMT2A | |
| SCHEMBL11825390 | 0.67 | KDM4E (0.44) | ALDH1A1RAB9AKMT2APTGS2KDM4E | |
| SCHEMBL26122772 | 0.67 | PTGS2 (0.47) | ALDH1A1RAB9ASMN1; SMN2KMT2APTGS2 | |
| SCHEMBL15941989 | 0.66 | FLT3 (0.59) | ALDH1A1RAB9AFLT3GSK3BSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019394-A1 | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS | G.D. Searle & Co. (US) | 2000-07-19 | — | — | EP | claimed |
| WO-1998052941-A1 | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS | G.D. SEARLE AND CO. (US) | 1998-11-26 | — | — | WO | claimed |
| EP-1019394-A1 | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS | G.D. Searle & Co. (US) | 2000-07-19 | — | — | EP | disclosed |
| WO-1998052941-A1 | PYRAZOLE DERIVATIVES AS p38 KINASE INHIBITORS | G.D. SEARLE AND CO. (US) | 1998-11-26 | — | — | WO | disclosed |