Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.51 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.51 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.48 |
| ▸ | ITGAV | P06756 | 1/20 | 0.48 |
| ▸ | MMP2 | P08253 | 1/20 | 0.48 |
| ▸ | MMP9 | P14780 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120405 | 0.95 | HTT (0.56) | HTTFOLH1TMPRSS11DSIRT2KEAP1 | |
| Hydrochloric Acid SCHEMBL8069339 | 0.89 | HTT (0.50) | HTTFOLH1SIRT2KEAP1NFE2L2 | |
| Trifluoroacetic Acid SCHEMBL8527990 | 0.86 | SIRT2 (0.46) | HTTFOLH1TMPRSS11DSIRT2KEAP1 | |
| Hydrochloric Acid SCHEMBL8068240 | 0.83 | HTT (0.53) | HTTFOLH1SIRT2KEAP1NFE2L2 | |
| SCHEMBL7318212 | 0.82 | FOLH1 (0.58) | HTTFOLH1SIRT2KEAP1NFE2L2 | |
| SCHEMBL7311020 | 0.82 | FOLH1 (0.58) | HTTFOLH1SIRT2KEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL7596809 | 0.81 | SIRT2 (0.48) | HTTFOLH1SIRT2MMP2MMP9 | |
| Hydrochloric Acid SCHEMBL8074447 | 0.81 | MMP2 (0.53) | HTTFOLH1SIRT2KEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL7600885 | 0.81 | SIRT2 (0.48) | HTTFOLH1SIRT2MMP2MMP9 | |
| SCHEMBL8111498 | 0.81 | ANPEP (0.59) | HTTKEAP1NFE2L2PLAULMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0680469-B1 | AMINOACID DERIVATES, MEDICAMENTS CONTAINING THESE COMPOUNDS AND PROCESS FOR PREPARING THE SAME | BOEHRINGER INGELHEIM PHARMA (DE) | 2000-04-26 | — | — | EP | disclosed |