Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | TMPRSS11D | O60235 | 1/20 | 0.46 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.45 |
| ▸ | ITGAV | P06756 | 2/20 | 0.45 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.43 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.43 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8120405 | 0.88 | HTT (0.56) | SIRT2TMPRSS11DFOLH1HTTKEAP1 | |
| SCHEMBL8111499 | 0.86 | HTT (0.52) | SIRT2TMPRSS11DITGB3ITGAVFOLH1 | |
| SCHEMBL8528566 | 0.77 | PSMB1 (0.53) | SIRT2CTSLITGB3ITGAVHTT | |
| Trifluoroacetic Acid SCHEMBL30905260 | 0.77 | ANPEP (0.52) | ITGB3ITGAVHTTPLAU | |
| Trifluoroacetic Acid SCHEMBL30685089 | 0.77 | DPP8 (0.61) | SIRT2FOLH1HTTKEAP1NFE2L2 | |
| Hydrochloric Acid SCHEMBL8068240 | 0.77 | HTT (0.53) | SIRT2CTSLFOLH1HTTKEAP1 | |
| Hydrochloric Acid SCHEMBL8069339 | 0.76 | HTT (0.50) | SIRT2CTSLFOLH1HTTKEAP1 | |
| SCHEMBL7318212 | 0.75 | FOLH1 (0.58) | SIRT2FOLH1HTTKEAP1NFE2L2 | |
| SCHEMBL7311020 | 0.75 | FOLH1 (0.58) | SIRT2FOLH1HTTKEAP1NFE2L2 | |
| Trifluoroacetic Acid SCHEMBL20263692 | 0.75 | CTSS (0.47) | CTSLITGB3ITGAVFOLH1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885186-A1 | AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997019911-A1 | AMINO ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS AND PROCESSES FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1997-06-05 | — | — | WO | disclosed |