Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CDYL2 | Q8N8U2 | 1/20 | 0.46 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SLC8B1 | Q6J4K2 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123403 | 0.91 | CDYL2 (0.46) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4710206 | 0.91 | CDYL2 (0.46) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4112411 | 0.91 | CDYL2 (0.46) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4710205 | 0.91 | CDYL2 (0.46) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4129636 | 0.91 | CDYL2 (0.43) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4123398 | 0.91 | CDYL2 (0.46) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4710208 | 0.91 | CDYL2 (0.46) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4129644 | 0.91 | CDYL2 (0.43) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4112406 | 0.91 | CDYL2 (0.46) | HTTHSD17B10MEN1KMT2ACDYL2 | |
| SCHEMBL4129633 | 0.91 | CDYL2 (0.43) | HTTHSD17B10MEN1KMT2ACDYL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0645378-B1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-08-23 | — | — | EP | disclosed |
| US-5698691-A | ANTICHOLESTEROL AGENT; SYNTHETASE INHIBITOR; FUNGICIDE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0645378-A1 | Condensed seven- or eight-membered heterocyclic compounds useful as squalene synthetase inhibitors | Takeda Chemical Industries, Ltd. (JP) | 1995-03-29 | — | — | EP | disclosed |