Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 2/20 | 0.49 |
| ▸ | GPR35 | Q9HC97 | 3/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.38 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.38 |
| ▸ | GABRE | P78334 | 1/20 | 0.38 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335367 | 0.84 | CFTR (0.50) | CFTRGPR35NOTUMSOS1MRGPRX4 | |
| SCHEMBL16929786 | 0.81 | CFTR (0.56) | CFTRGPR35NOTUMSOS1KDM4E | |
| SCHEMBL8337100 | 0.79 | GPR35 (0.48) | CFTRGPR35NOTUMSOS1MRGPRX4 | |
| SCHEMBL15390859 | 0.78 | ABL1 (0.46) | CFTRPDK2KDM4EPDK4ABL1 | |
| SCHEMBL23141224 | 0.78 | CFTR (0.62) | CFTRNOTUMSOS1MRGPRX4KDM4E | |
| SCHEMBL425243 | 0.78 | CFTR (0.67) | CFTRNOTUMSOS1MRGPRX4PDK2 | |
| SCHEMBL8332067 | 0.77 | NOTUM (0.48) | CFTRGPR35NOTUMMRGPRX4PDK2 | |
| SCHEMBL2657595 | 0.76 | MRGPRX4 (0.51) | CFTRGPR35NOTUMSOS1MRGPRX4 | |
| SCHEMBL28749071 | 0.75 | SOS1 (0.61) | CFTRGPR35NOTUMSOS1MRGPRX4 | |
| SCHEMBL8117858 | 0.75 | GPR35 (0.43) | CFTRGPR35NOTUMMRGPRX4GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6153651-A | Ortho-substituted benzoylguanidines, process for their preparation, their use as a medicament or diagnostic, and medicament comprising them | HOECHST AKTIENGESELLSCHAFT (DE) | 2000-11-28 | — | — | US | disclosed |
| US-5856574-A | ANTIISCHEMIC AGENTS; ANTIARRTHYMIA AGENTS | HOECHST AKTIENGESELLSCHAFT (DE) | 1999-01-05 | — | — | US | disclosed |