SCHEMBL8112554

SCHEMBL8112554

COc1ccc(C2(C(=O)OC3CCN(C)CC3)CCC2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RAB9A P51151 1/20 0.54
SIGMAR1 Q99720 2/20 0.49
CYP3A4 P08684 1/20 0.48
CYP2C19 P33261 1/20 0.48
CHRM3 P20309 3/20 0.47
CHRM5 P08912 2/20 0.47
CHRM1 P11229 2/20 0.47
HTT P42858 1/20 0.45
EP300 Q09472 2/20 0.44
CREBBP Q92793 2/20 0.44
TET3 O43151 1/20 0.44
KMT2A Q03164 1/20 0.44
FBXL19 Q6PCT2 1/20 0.44
CXXC5 Q7LFL8 1/20 0.44
TET1 Q8NFU7 1/20 0.44
KDM2B Q8NHM5 1/20 0.44
CXXC4 Q9H2H0 1/20 0.44
KDM2A Q9Y2K7 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPK1 P28482 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8106501 0.87 SCN1A (0.57) CHRM3CHRM5CHRM1KMT2AHRH3
Hydrochloric Acid SCHEMBL8097354 0.85 CHRM3 (0.62) SIGMAR1CHRM3CHRM5CHRM1KMT2A
SCHEMBL4734246 0.83 CHRM3 (0.67) SIGMAR1CHRM3CHRM5CHRM1KMT2A
SCHEMBL4733406 0.82 CHRM3 (0.69) SIGMAR1CYP3A4CYP2C19CHRM3CHRM5
SCHEMBL4734319 0.82 CHRM3 (0.69) SIGMAR1CYP3A4CYP2C19CHRM3CHRM5
Hydrochloric Acid SCHEMBL1805907 0.82 CHRM3 (0.65) SIGMAR1CHRM3CHRM5CHRM1KMT2A
SCHEMBL4733989 0.82 CHRM3 (0.69) SIGMAR1CYP3A4CYP2C19CHRM3CHRM5
Hydrochloric Acid SCHEMBL8110706 0.79 CHRM3 (0.57) SIGMAR1CHRM3CHRM5CHRM1HTT
SCHEMBL8586765 0.76 KDM4E (0.58) SIGMAR1CYP3A4CYP2C19CHRM1EP300
Hydrochloric Acid SCHEMBL8110466 0.76 CHRM3 (0.68) SIGMAR1CYP3A4CYP2C19CHRM3CHRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6124354-A TREATMENT OF URINARY INCONTINENCE OR IRRITABLE BOWEL SYNDROME PHARMACIA & UPJOHN AB (SE) 2000-09-26 US disclosed
EP-0923536-A1 ARYLCYCLOALKANE CARBOXYLIC ESTERS, THEIR USE, PHARMACEUTICAL COMPOSITIONS AND PREPARATION Pharmacia & Upjohn Aktiebolag (SE) 1999-06-23 EP disclosed
WO-1998004517-A1 ARYLCYCLOALKANE CARBOXYLIC ESTERS, THEIR USE, PHARMACEUTICAL COMPOSITIONS AND PREPARATION PHARMACIA & UPJOHN AB (SE) 1998-02-05 WO disclosed