Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3E | A5X5Y0 | 6/20 | 0.78 |
| ▸ | HTR3B | O95264 | 6/20 | 0.78 |
| ▸ | HTR3A | P46098 | 6/20 | 0.78 |
| ▸ | HTR3D | Q70Z44 | 6/20 | 0.78 |
| ▸ | HTR3C | Q8WXA8 | 6/20 | 0.78 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | CASP1 | P29466 | 1/20 | 0.53 |
| ▸ | CASP7 | P55210 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8111177 | 0.87 | HTR3E (1.00) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8110805 | 0.87 | HTR3E (0.72) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8569971 | 0.80 | HTR3E (0.73) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8569563 | 0.78 | HTR3E (0.75) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8563997 | 0.78 | HTR3E (0.78) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL29389858 | 0.78 | MAPT (0.76) | KDM4EMAPTTSHRHSD17B10ALDH1A1 | |
| SCHEMBL17895090 | 0.77 | HTR3E (0.64) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL11488992 | 0.74 | MAPK8 (0.63) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL8116881 | 0.73 | HRH4 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C | |
| SCHEMBL120846 | 0.73 | MAPK8 (0.54) | HTR3EHTR3BHTR3AHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6124287-A | TREATING DEPRESSION | BIOMEDICA FOSCAMA INDUSTRIA CHIMICOFARMACEUTICA S.P.A. (IT) | 2000-09-26 | — | — | US | disclosed |
| EP-0865442-B1 | IMIDAZO[1,2-a]QUINOXALIN-4-AMINES ACTIVE AS ADENOSINE ANTAGONISTS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS THEREOF | FOSCAMA BIOMED CHIM FARMA (IT) | 2000-07-05 | — | — | EP | disclosed |