Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 8/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 6/20 | 0.47 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL154546 | 0.82 | OPRM1 (0.40) | OPRM1OPRD1OPRK1 | |
| SCHEMBL9738514 | 0.80 | OPRM1 (0.52) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL8407436 | 0.77 | OPRM1 (0.46) | OPRM1OPRD1OPRK1SMN1; SMN2 | |
| SCHEMBL8407441 | 0.77 | OPRM1 (0.46) | OPRM1OPRD1OPRK1SMN1; SMN2 | |
| SCHEMBL11336417 | 0.77 | ALDH1A1 (0.37) | OPRM1SMN1; SMN2 | |
| SCHEMBL14214939 | 0.75 | OPRM1 (0.51) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL27770227 | 0.73 | GRIN1 (0.43) | SMN1; SMN2GRIN1GRIN2A | |
| SCHEMBL27722462 | 0.73 | POLB (0.45) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL8763832 | 0.73 | OPRM1 (0.50) | OPRM1OPRD1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL18821238 | 0.73 | POLB (0.47) | OPRM1SLC6A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666856-B1 | 4-ARYLMETHYLOXYMETHYL PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME (GB) | 2000-01-05 | — | — | EP | disclosed |
| US-5620989-A | NERVOUS SYSTEM AND PSYCHOLOGICAL DISORDERS; PARTICULARLY ANTAGONISTIC FOR SUBSTANCE P | MERCK SHARP & DOHME LIMITED (GB) | 1997-04-15 | — | — | US | disclosed |
| EP-0666856-A1 | 4-ARYLMETHYLOXYMETHYL PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010165-A1 | 4-ARYLMETHYLOXYMETHYL PIPERIDINES AS TACHYKININ ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1994-05-11 | — | — | WO | disclosed |