Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 4/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | GNRHR | P30968 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8115213 | 1.00 | TBXAS1 (0.38) | TBXAS1HDAC6LMNAMAPTALDH1A1 | |
| SCHEMBL6970047 | 0.91 | POLB (0.39) | LMNAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL6965153 | 0.91 | PDE4A (0.37) | LMNAMAPTALDH1A1POLBFFAR1 | |
| SCHEMBL6965158 | 0.91 | PDE4A (0.37) | LMNAMAPTALDH1A1POLBFFAR1 | |
| SCHEMBL6973833 | 0.91 | MAPT (0.36) | LMNAMAPTALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL6973612 | 0.89 | KMT2A (0.39) | LMNAMAPTALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL7083710 | 0.89 | KMT2A (0.38) | LMNAMAPTALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL7081285 | 0.89 | MAPT (0.37) | LMNAMAPTALDH1A1POLBRXFP1 | |
| SCHEMBL7084614 | 0.88 | FKBP1A (0.38) | LMNAMAPTALDH1A1CYP19A1CYP11B1 | |
| SCHEMBL6968703 | 0.88 | MAPT (0.37) | LMNAMAPTALDH1A1CYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6147097-A | METHOD FOR TREATING AIDS | SHIONOGI & CO., LTD. (JP) | 2000-11-14 | — | — | US | disclosed |
| US-5910506-A | IMIDAZOLE DERIVATIVES, E.G.5-(3,5-DICHLOROPHENYLTHIO)-1,2-DIMETHYL-4-ISOPROPYL-1H-IMIDAZOLE; VIRICIDES; AIDS; NONTOXIC | SHIONOGI & CO., LTD. (JP) | 1999-06-08 | — | — | US | disclosed |
| EP-0786455-A1 | IMIDAZOLE DERIVATIVE | SHIONOGI & CO., LTD. (JP) | 1997-07-30 | — | — | EP | disclosed |