Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.61 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.61 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126363 | 0.81 | LMNA (0.61) | LMNATDP1CYP19A1HTTALDH1A1 | |
| SCHEMBL920902 | 0.81 | LMNA (0.61) | LMNATDP1CYP19A1HTTALDH1A1 | |
| SCHEMBL8124450 | 0.81 | LMNA (0.61) | LMNATDP1CYP19A1HTTALDH1A1 | |
| SCHEMBL8124884 | 0.81 | LMNA (0.61) | LMNATDP1CYP19A1HTTALDH1A1 | |
| SCHEMBL8121297 | 0.79 | LMNA (0.59) | LMNATDP1CYP19A1HTTALDH1A1 | |
| SCHEMBL25268910 | 0.79 | LTA4H (0.48) | HTTALDH1A1SMN1; SMN2LTA4H | |
| SCHEMBL676142 | 0.76 | LMNA (0.82) | LMNATDP1CYP19A1HTTALDH1A1 | |
| SCHEMBL30535283 | 0.76 | LMNA (0.82) | LMNATDP1CYP19A1HTTALDH1A1 | |
| SCHEMBL8124461 | 0.76 | LMNA (0.50) | LMNATDP1CYP19A1HTTALDH1A1 | |
| SCHEMBL694392 | 0.75 | LMNA (0.62) | LMNATDP1CYP19A1HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |