Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | CPA3 | P15088 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.33 |
| ▸ | SMYD2 | Q9NRG4 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.32 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.32 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9115853 | 1.00 | ALDH1A1 (0.34) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL8118695 | 1.00 | ALDH1A1 (0.34) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL5026303 | 0.85 | CYSLTR2 (0.37) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL5026306 | 0.85 | CYSLTR2 (0.37) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL9523633 | 0.85 | GAA (0.36) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL8122701 | 0.85 | GAA (0.36) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL8122702 | 0.85 | GAA (0.36) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL3404476 | 0.84 | LTA4H (0.38) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL9123979 | 0.80 | SMYD2 (0.32) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 | |
| SCHEMBL8116571 | 0.80 | SMYD2 (0.32) | ALDH1A1CYP2D6CYP1A2TSHRCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707481-B1 | L-2',3'-DIDEOXY NUCLEOSIDE ANALOGS AS ANTI-HEPATITIS B (HBV) AND ANTI-HIV AGENTS | UNIV YALE (US) | 2000-08-16 | — | — | EP | disclosed |
| US-5830881-A | L-2'3',dideoxy nucleoside analogs as anti-hepatitus B (HBV) agents | YALE UNIVERSITY (US) | 1998-11-03 | — | — | US | disclosed |
| US-5631239-A | VIRICIDES FOR HEPATITIS | YALE UNIVERSITY (US) | 1997-05-20 | — | — | US | disclosed |
| US-5627160-A | L-2',3'-dideoxy nucleoside analogs as anti-hepatitis B (HBV) and anti-HIV agents | YALE UNIVERSITY (US) | 1997-05-06 | — | — | US | disclosed |
| US-5561120-A | LOW TOXICITY TO HOST CELLS | YALE UNIVERSITY (US) | 1996-10-01 | — | — | US | disclosed |
| EP-0707481-A4 | — | — | 1996-05-29 | — | — | EP | disclosed |
| EP-0707481-A1 | L-2',3'-DIDEOXY NUCLEOSIDE ANALOGS AS ANTI-HEPATITIS B (HBV) AND ANTI-HIV AGENTS | YALE UNIVERSITY (US) | 1996-04-24 | — | — | EP | disclosed |
| WO-1994027616-A1 | L-2',3'-DIDEOXY NUCLEOSIDE ANALOGS AS ANTI-HEPATITIS B (HBV) AND ANTI-HIV AGENTS | YALE UNIVERSITY (US) | 1994-12-08 | — | — | WO | disclosed |