SCHEMBL812164

SCHEMBL812164

C[Si](C)(C)C#CC(=O)CF

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1478279 0.77 TDP1 (0.32)
SCHEMBL5804866 0.75 TSHR (0.30)
SCHEMBL1572411 0.71
SCHEMBL9303765 0.71 ALDH1A1 (0.39)
SCHEMBL302058 0.71 EGLN1 (0.41)
SCHEMBL11347415 0.70 CES1 (0.42)
SCHEMBL11074881 0.69
SCHEMBL31270755 0.69 ALDH1A1 (0.30)
SCHEMBL11267132 0.69
SCHEMBL9303288 0.67 GABRR1 (0.34)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1851214-B1 ISOXAZOLINE DERIVATIVE AND NOVEL PROCESS FOR ITS PREPARATION LG LIFE SCIENCES LTD (KR) 2012-09-05 EP disclosed
US-8044080-B2 Isoxazoline derivative and novel process for its preparation LG LIFE SCIENCES LTD. (KR) 2011-10-25 US disclosed
US-7906676-B2 Process for preparing 3-amino-5-fluoro-4-dialkoxypentanoic acid ester LG LIFE SCIENCES LTD. (KR) 2011-03-15 US disclosed
US-7906676-B2 Process for preparing 3-amino-5-fluoro-4-dialkoxypentanoic acid ester LG LIFE SCIENCES LTD. (KR) 2011-03-15 US disclosed
US-20100160370-A1 METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITIONS GILEAD SCIENCES, INC. (US) 2010-06-24 US disclosed
US-20100036158-A1 NOVEL PROCESS FOR PREPARING 3-AMINO-5-FLUORO-4-DIALKOXYPENTANOIC ACID ESTER LG LIFE SCIENCES LTD. (KR) 2010-02-11 US disclosed
US-20100036158-A1 NOVEL PROCESS FOR PREPARING 3-AMINO-5-FLUORO-4-DIALKOXYPENTANOIC ACID ESTER LG LIFE SCIENCES LTD. (KR) 2010-02-11 US disclosed
WO-2010005766-A1 USE OF PHARMACEUTICAL COMPOSITIONS COMPRISING A CASPASE INHIBITOR FOR TREATING INTERSTITIAL LUNG DISEASES GILEAD SCIENCES, INC. (US) 2010-01-14 WO disclosed
US-20100008867-A1 METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITIONS GILEAD SCIENCES, INC. (US) 2010-01-14 US disclosed
WO-2010005765-A1 METHOD OF TREATMENT AND PHARMACEUTICAL COMPOSITIONS GILEAD SCIENCES, INC. (US) 2010-01-14 WO disclosed
EP-2051959-A1 A NOVEL PROCESS FOR PREPARING 3-AMINO-5-FLUORO-4-DIALKOXYPENTANOIC ACID ESTER LG Life Sciences Ltd. (KR) 2009-04-29 EP disclosed
US-20080262032-A1 Isoxazoline Derivative and Novel Process for Its Preparation LG CHEM, LTD. (KR) 2008-10-23 US disclosed
WO-2008020691-A1 A NOVEL PROCESS FOR PREPARING 3-AMINO-5-FLUORO-4-DIALKOXYPENTANOIC ACID ESTER LG LIFE SCIENCES LTD. (KR) 2008-02-21 WO disclosed
EP-1851214-A1 ISOXAZOLINE DERIVATIVE AND NOVEL PROCESS FOR ITS PREPARATION LG Life Sciences Ltd. (KR) 2007-11-07 EP disclosed
WO-2006090997-A1 ISOXAZOLINE DERIVATIVE AND NOVEL PROCESS FOR ITS PREPARATION LG LIFE SCIENCES LTD. (KR) 2006-08-31 WO disclosed