Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 1/20 | 0.39 |
| ▸ | ARG2 | P78540 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.33 |
| ▸ | PGR | P06401 | 1/20 | 0.33 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8106291 | 0.91 | CYP2D6 (0.33) | ARG1ARG2CYP1A2TSHRALDH1A1 | |
| SCHEMBL8123993 | 0.80 | ARG1 (0.42) | ARG1ARG2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8116636 | 0.79 | ARG1 (0.40) | ARG1ARG2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL16757166 | 0.78 | MGAM (0.36) | ARG1ARG2CYP1A2TSHRALOX15 | |
| SCHEMBL6170436 | 0.72 | ARG1 (0.37) | ARG1ARG2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL17395338 | 0.72 | ARG1 (0.37) | ARG1ARG2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8115611 | 0.71 | CA12 (0.41) | ARG1ARG2TDP1 | |
| SCHEMBL17393299 | 0.71 | SLC6A4 (0.47) | ARG1ARG2ALDH1A1ALOX15TDP1 | |
| SCHEMBL27643221 | 0.70 | CYP1A2 (0.55) | CYP1A2TSHRALDH1A1ALOX15TDP1 | |
| Hydrochloric Acid SCHEMBL17393298 | 0.70 | CYP2D6 (0.46) | ARG1ARG2ALOX15KMT2ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |