Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ARG1 | P05089 | 1/20 | 0.42 |
| ▸ | ARG2 | P78540 | 1/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.36 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.36 |
| ▸ | CPB2 | Q96IY4 | 8/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 5/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116636 | 0.94 | ARG1 (0.40) | ARG1ARG2CYP4F2CYP4A11CYP2D6 | |
| SCHEMBL8123261 | 0.80 | ARG1 (0.39) | ARG1ARG2CYP4F2CYP4A11CYP2D6 | |
| SCHEMBL17395338 | 0.76 | ARG1 (0.37) | ARG1ARG2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL6170436 | 0.76 | ARG1 (0.37) | ARG1ARG2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8115611 | 0.75 | CA12 (0.41) | ARG1ARG2 | |
| SCHEMBL8106291 | 0.75 | CYP2D6 (0.33) | ARG1ARG2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL8123898 | 0.73 | CA12 (0.42) | ARG1ARG2 | |
| SCHEMBL5730696 | 0.73 | CTSK (0.34) | ARG1ARG2CYP2D6SLC6A2SLC6A4 | |
| SCHEMBL516843 | 0.73 | CYP4F2 (0.51) | CYP4F2CYP4A11CPB2 | |
| SCHEMBL9637006 | 0.72 | ARG1 (0.32) | ARG1ARG2CYP2D6SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1056733-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 2000-12-06 | — | — | EP | disclosed |
| WO-1999042458-A1 | HISTAMINE H3 RECEPTOR LIGANDS | JAMES BLACK FOUNDATION LIMITED (GB) | 1999-08-26 | — | — | WO | disclosed |