Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | APLNR | P35414 | 4/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.35 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.34 |
| ▸ | TOP1 | P11387 | 1/20 | 0.34 |
| ▸ | FPR2 | P25090 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13470654 | 0.95 | PDE2A (0.43) | PDE2AAPLNRDGAT1BCAT2TOP1 | |
| SCHEMBL13464609 | 0.94 | PDE2A (0.42) | PDE2AAPLNRTOP1MEN1LMNA | |
| SCHEMBL11899944 | 0.92 | PDE2A (0.45) | PDE2AAPLNRDGAT1FPR2SLC6A4 | |
| SCHEMBL13470657 | 0.87 | PDE2A (0.40) | PDE2AAPLNRDGAT1BCAT2FPR2 | |
| SCHEMBL23729241 | 0.87 | ADRA2C (0.41) | PDE2ATOP1MEN1LMNATP53 | |
| SCHEMBL147207 | 0.84 | PDE2A (0.60) | PDE2AAPLNRDGAT1FPR2LMNA | |
| SCHEMBL7346953 | 0.83 | ADRB2 (0.42) | PDE2AAPLNRDGAT1NPSR1KDM4E | |
| SCHEMBL22632532 | 0.82 | ADRA2C (0.40) | TOP1MEN1LMNATP53HPGD | |
| SCHEMBL16070599 | 0.79 | PDE2A (0.41) | PDE2AAPLNRDGAT1LMNANPSR1 | |
| SCHEMBL1145071 | 0.78 | ADRA2C (0.41) | PDE2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519353-B1 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO (JP) | 2000-08-16 | — | — | EP | disclosed |
| US-5334716-A | Preventing testosteron 5a-reductase mediated diseases; alopecia, acne, prostatism | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-08-02 | — | — | US | disclosed |
| EP-0519353-A2 | Indolizin derivatives, process for their preparation and pharmaceutical composition containing them | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-12-23 | — | — | EP | disclosed |