Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 2/20 | 0.47 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | BACE1 | P56817 | 1/20 | 0.45 |
| ▸ | MGAM | O43451 | 1/20 | 0.45 |
| ▸ | SI | P14410 | 1/20 | 0.45 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10595717 | 1.00 | STIM1 (0.47) | STIM1ORAI1GAAALDH1A1LMNA | |
| SCHEMBL357250 | 0.96 | NFE2L2 (0.49) | STIM1ORAI1GAAALDH1A1LMNA | |
| SCHEMBL29788121 | 0.96 | NFE2L2 (0.49) | STIM1ORAI1GAAALDH1A1LMNA | |
| Iodide SCHEMBL29162112 | 0.94 | NFE2L2 (0.47) | STIM1ORAI1GAAALDH1A1LMNA | |
| Methyl Alcohol SCHEMBL28815313 | 0.92 | FFAR4 (0.48) | STIM1ORAI1GAAALDH1A1LMNA | |
| Toluene SCHEMBL27771682 | 0.89 | NFE2L2 (0.45) | STIM1ORAI1GAAALDH1A1LMNA | |
| SCHEMBL3643542 | 0.89 | NFE2L2 (0.46) | STIM1ORAI1GAAALDH1A1LMNA | |
| SCHEMBL434622 | 0.86 | BACE1 (0.44) | STIM1ORAI1GAAALDH1A1LMNA | |
| SCHEMBL1044693 | 0.85 | NFE2L2 (0.51) | STIM1ORAI1GAAALDH1A1SMN1; SMN2 | |
| SCHEMBL16673937 | 0.84 | CYP1A1 (0.53) | STIM1ORAI1GAASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |