Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 10/20 | 0.74 |
| ▸ | SRC | P12931 | 8/20 | 0.74 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | USP7 | Q93009 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8134775 | 0.85 | FGFR1 (1.00) | FGFR1SRCKDR | |
| SCHEMBL8807633 | 0.85 | FGFR1 (1.00) | FGFR1SRCKDR | |
| SCHEMBL8134814 | 0.82 | FGFR1 (0.66) | FGFR1SRCPDPK1BACE1KDR | |
| SCHEMBL11115455 | 0.74 | FGFR1 (0.55) | FGFR1SRCMAP4K4USP7ADORA2A | |
| SCHEMBL18227070 | 0.74 | TERT (0.49) | FGFR1SRCBACE1HSP90AA1HSP90AB1 | |
| SCHEMBL4500154 | 0.71 | PLA2G7 (0.53) | FGFR1SRCPDPK1BACE1MAP4K4 | |
| SCHEMBL14244969 | 0.71 | ABL1 (0.63) | FGFR1SRCPDPK1BACE1KDR | |
| SCHEMBL1517012 | 0.71 | ADORA1 (0.47) | FGFR1SRCPDPK1KDRHSP90AA1 | |
| SCHEMBL4186547 | 0.70 | DHFR (0.56) | FGFR1SRCHSP90AA1HSP90AB1ADORA2A | |
| SCHEMBL15488575 | 0.70 | CHRM5 (0.48) | FGFR1SRCMAP4K4USP7HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790997-B1 | 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2000-03-22 | — | — | EP | claimed |
| US-5952342-A | 1,6-NAPHTHYRIDINES EFFECTIVE IN TREATING ATHEROSCLEROSIS, RESTENOSIS AND PSORIASIS; ANTICARCINOGENIC AND -PROLIFERATIVE AGENTS; BACTERICIDES | WARNER-LAMBERT COMPANY (US) | 1999-09-14 | — | — | US | claimed |
| EP-0790997-A2 | 6-ARYL PYRIDO( 2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1997-08-27 | — | — | EP | claimed |
| WO-1996015128-A2 | 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-05-23 | — | — | WO | claimed |
| CN-1085666-C | 6-aryl pyrido (2,3-d) pyrimidines and naphthyridines for inhibiting protein tyrosine kinase medicated cellular proliferation | WARNER LAMBERT CO (US) | 2002-05-29 | — | — | CN | disclosed |
| EP-0790997-B1 | 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2000-03-22 | — | — | EP | disclosed |
| US-5952342-A | 1,6-NAPHTHYRIDINES EFFECTIVE IN TREATING ATHEROSCLEROSIS, RESTENOSIS AND PSORIASIS; ANTICARCINOGENIC AND -PROLIFERATIVE AGENTS; BACTERICIDES | WARNER-LAMBERT COMPANY (US) | 1999-09-14 | — | — | US | disclosed |
| US-5733913-A | TREATING ATHEROSCLEROSIS, POSTSURGICAL RESTENOSIS | WARNER-LAMBERT COMPANY | 1998-03-31 | — | — | US | disclosed |
| CN-1169726-A | 6-aryl pyrido (2,3-d) pyrimidines and naphthyridines for inhibiting protein tyrosine kinase medicated cellular proliferation | WARNER LAMBERT CO (US) | 1998-01-07 | — | — | CN | disclosed |
| EP-0790997-A2 | 6-ARYL PYRIDO( 2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996015128-A2 | 6-ARYL PYRIDO[2,3-d]PYRIMIDINES AND NAPHTHYRIDINES FOR INHIBITING PROTEIN TYROSINE KINASE MEDIATED CELLULAR PROLIFERATION | WARNER-LAMBERT COMPANY (US) | 1996-05-23 | — | — | WO | disclosed |