Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 3/20 | 0.38 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3636361 | 0.85 | HSD11B1 (0.42) | HSD11B1ARTRPA1NOTUM | |
| SCHEMBL2437985 | 0.81 | HSD11B1 (0.38) | HSD11B1ARTRPA1NOTUM | |
| SCHEMBL1370373 | 0.79 | TSHR (0.39) | HTTNOTUM | |
| SCHEMBL9004918 | 0.79 | PGR (0.45) | HSD11B1ARTRPA1TRPM8HTT | |
| SCHEMBL7532639 | 0.77 | NPC1 (0.38) | HTTNOTUM | |
| SCHEMBL12817256 | 0.77 | HSD11B1 (0.41) | HSD11B1ARTRPA1TRPM8TRPV1 | |
| SCHEMBL8129046 | 0.77 | ACHE (0.46) | NOTUM | |
| SCHEMBL5541462 | 0.75 | HSD11B1 (0.55) | HSD11B1ARTRPA1TRPM8TRPV1 | |
| SCHEMBL6334156 | 0.75 | AR (0.36) | HSD11B1ARHTTGPBAR1 | |
| SCHEMBL2049471 | 0.75 | HSD11B1 (0.46) | HSD11B1TRPA1NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1028945-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | Amgen Inc. (US) | 2000-08-23 | — | — | EP | disclosed |
| WO-1999024404-A1 | SUBSTITUTED PYRIDINE COMPOUNDS AS ANTI-INFLAMMATORY AGENTS | AMGEN INC. (US) | 1999-05-20 | — | — | WO | disclosed |