Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MBOAT4 | Q96T53 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 1/20 | 0.42 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.42 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8117570 | 0.83 | EGLN2 (0.48) | KDM4EALDH1A1HPGDPOLBTP53 | |
| SCHEMBL8126098 | 0.83 | EGLN2 (0.50) | KDM4EALDH1A1HPGDPOLBTSHR | |
| SCHEMBL8124326 | 0.81 | TP53 (0.52) | KDM4EALDH1A1HPGDPOLBTP53 | |
| SCHEMBL868326 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1HPGDPOLBTSHR | |
| SCHEMBL6806818 | 0.79 | MBOAT4 (0.45) | KDM4EALDH1A1HPGDPOLBTP53 | |
| SCHEMBL5332533 | 0.79 | ALDH1A1 (0.62) | KDM4EALDH1A1HPGDPOLBTP53 | |
| SCHEMBL8127316 | 0.78 | EGLN2 (0.51) | KDM4EALDH1A1HPGDTP53TSHR | |
| SCHEMBL8117996 | 0.77 | KDM4E (0.47) | KDM4EALDH1A1HPGDPOLBTSHR | |
| SCHEMBL4820351 | 0.77 | TSHR (0.45) | KDM4EALDH1A1HPGDPOLBTP53 | |
| SCHEMBL8117510 | 0.76 | KDM4E (0.54) | KDM4EALDH1A1HPGDPOLBTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0782997-B1 | Triazolopyrimidine derivatives | SHELL INT RESEARCH (NL) | 2000-04-26 | — | — | EP | claimed |
| EP-0782997-A2 | Triazolopyrimidine derivatives | SHELL INTERNATIONALE RESEARCHMAATSCHAPPIJ B.V. (NL) | 1997-07-09 | — | — | EP | claimed |
| EP-0999856-A2 | RADIOPHARMACEUTICALS FOR IMAGING INFECTION AND INFLAMMATION | Du Pont Pharmaceuticals Company (US) | 2000-05-17 | — | — | EP | disclosed |
| EP-0782997-B1 | Triazolopyrimidine derivatives | SHELL INT RESEARCH (NL) | 2000-04-26 | — | — | EP | disclosed |
| WO-1998015295-A2 | RADIOPHARMACEUTICALS FOR IMAGING INFECTION AND INFLAMMATION | DUPONT PHARMACEUTICALS COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |