SCHEMBL8126331

SCHEMBL8126331

FC(F)(F)c1cc(Oc2cccc(-c3cccs3)n2)cs1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.46
ALDH1A1 P00352 8/20 0.46
HPGD P15428 6/20 0.46
KMT2A Q03164 4/20 0.46
L3MBTL1 Q9Y468 3/20 0.46
MAPT P10636 3/20 0.46
TDP1 Q9NUW8 3/20 0.46
MEN1 O00255 2/20 0.46
SMN1; SMN2 Q16637 3/20 0.40
GAA P10253 5/20 0.39
LMNA P02545 2/20 0.39
SDHB P21912 2/20 0.39
GLA P06280 2/20 0.39
RXFP1 Q9HBX9 2/20 0.38
CCNE2 O96020 1/20 0.38
CCNE1 P24864 1/20 0.38
CDK2 P24941 1/20 0.38
RAB9A P51151 3/20 0.38
NPC1 O15118 2/20 0.38
HSD17B10 Q99714 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5548596 0.79 CHRM5 (0.38) MAPTMAPK1
SCHEMBL8121468 0.75 MAPT (0.52) KDM4EALDH1A1L3MBTL1MAPTGAA
SCHEMBL23925887 0.72 HSD17B14 (0.62) KDM4EALDH1A1HPGDKMT2AL3MBTL1
SCHEMBL8111372 0.72 MMP13 (0.37) KDM4EALDH1A1HPGDGAALMNA
SCHEMBL8120723 0.72 SCN9A (0.36) KDM4EALDH1A1KMT2AMAPTMEN1
SCHEMBL8111972 0.72 HSD17B14 (0.38) KDM4EALDH1A1HPGDKMT2AL3MBTL1
SCHEMBL5211817 0.71 NPSR1 (0.38) KDM4EALDH1A1HPGDKMT2AL3MBTL1
SCHEMBL8119862 0.70 MMP13 (0.39) KDM4EKMT2AL3MBTL1TDP1MEN1
SCHEMBL8134141 0.69
SCHEMBL8126135 0.69 MAPT (0.34) ALDH1A1L3MBTL1MAPTSMN1; SMN2MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1028959-A1 HERBICIDAL FURANYL- AND THIENYLOXYAZINES AMERICAN CYANAMID COMPANY (US) 2000-08-23 EP claimed
WO-1999024427-A1 HERBICIDAL FURANYL- AND THIENYLOXYAZINES AMERICAN CYANAMID COMPANY (US) 1999-05-20 WO claimed
EP-1028959-A1 HERBICIDAL FURANYL- AND THIENYLOXYAZINES AMERICAN CYANAMID COMPANY (US) 2000-08-23 EP disclosed
WO-1999024427-A1 HERBICIDAL FURANYL- AND THIENYLOXYAZINES AMERICAN CYANAMID COMPANY (US) 1999-05-20 WO disclosed