Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 1/20 | 0.45 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8126642 | 1.00 | MAPT (0.59) | MAPTPTGS2MAOBALDH1A1RAB9A | |
| SCHEMBL8126650 | 1.00 | MAPT (0.59) | MAPTPTGS2MAOBALDH1A1RAB9A | |
| SCHEMBL28573768 | 0.88 | MAPT (0.59) | MAPTMAOBALDH1A1RAB9AATM | |
| SCHEMBL15835585 | 0.87 | CASP6 (0.58) | MAPTTSHRCASP6LMNAAKR1C3 | |
| SCHEMBL22672627 | 0.85 | MAPT (0.49) | MAPTPTGS2ALDH1A1RAB9AATM | |
| SCHEMBL6172610 | 0.85 | PTGS2 (0.48) | MAPTPTGS2ALDH1A1RAB9AATM | |
| SCHEMBL6172600 | 0.85 | PTGS2 (0.48) | MAPTPTGS2ALDH1A1RAB9AATM | |
| SCHEMBL3017268 | 0.82 | MAPT (0.62) | MAPTPTGS2MAOBALDH1A1RAB9A | |
| SCHEMBL3017265 | 0.82 | MAPT (0.62) | MAPTPTGS2MAOBALDH1A1RAB9A | |
| SCHEMBL25590305 | 0.81 | MAPT (0.51) | MAPTALDH1A1TSHRCASP6PDE7A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER INC. (US) | 2000-10-25 | — | — | EP | disclosed |
| WO-1999035130-A1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER PHARMACEUTICALS INC. (JP) | 1999-07-15 | — | — | WO | disclosed |