Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6172600 | 1.00 | PTGS2 (0.48) | PTGS2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9384428 | 0.85 | VCAM1 (0.53) | PTGS2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9384423 | 0.85 | VCAM1 (0.53) | PTGS2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8126644 | 0.85 | MAPT (0.59) | PTGS2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8126642 | 0.85 | MAPT (0.59) | PTGS2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL8126650 | 0.85 | MAPT (0.59) | PTGS2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL3071975 | 0.84 | KMT2A (0.57) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL3601937 | 0.84 | KMT2A (0.57) | MEN1KMT2AMAPTALDH1A1RAB9A | |
| SCHEMBL7204425 | 0.83 | PTGS2 (0.50) | PTGS2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL13145899 | 0.83 | ALDH1A1 (0.60) | PTGS2MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1045833-B1 | 2,3-SUBSTITUTED INDOLE COMPOUNDS AS COX-2 INHIBITORS | PFIZER (US) | 2005-11-02 | — | — | EP | disclosed |
| US-6608070-B1 | Useful for treatment of medical condition in which prostaglandins are implicated as pathogens | NAKAO KAZUNARI (JP) | 2003-08-19 | — | — | US | disclosed |