Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.50 |
| ▸ | MAOA | P21397 | 1/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | DAO | P14920 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10578987 | 0.91 | HTT (0.56) | MAOBMAOAAPPCA1CA2 | |
| SCHEMBL8125745 | 0.83 | RAB9A (0.47) | MAOBMAOAAPPALDH1A1KDM4E | |
| SCHEMBL17041364 | 0.83 | MAOB (0.56) | MAOBMAOAAPPCA1CA2 | |
| SCHEMBL6152469 | 0.83 | ALDH1A1 (0.53) | MAOBMAOAAPPCA1CA2 | |
| SCHEMBL418525 | 0.79 | ALDH1A1 (0.59) | MAOBMAOAAPPCA1CA2 | |
| SCHEMBL1323789 | 0.77 | APP (0.53) | MAOBMAOAAPPCA1CA2 | |
| SCHEMBL24471100 | 0.77 | APP (0.49) | MAOBMAOAAPPCA1CA2 | |
| SCHEMBL11986370 | 0.76 | APP (0.52) | MAOBMAOAAPPCA1CA2 | |
| SCHEMBL9808184 | 0.76 | ALDH1A1 (0.56) | MAOBMAOAAPPCA1CA2 | |
| SCHEMBL1738329 | 0.76 | APP (0.52) | MAOBMAOAAPPCA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0836606-B1 | CONDENSED THIAZOLE DERIVATIVES, HAVING 5-HT RECEPTOR AFFINITY | KNOLL AG (DE) | 2000-08-30 | — | — | EP | disclosed |
| US-5869492-A | TREATING CENTRAL NERVOUS SYSTEM DISORDERS | KNOLL AKTIENGESELLSCHAFT (DE) | 1999-02-09 | — | — | US | disclosed |