Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.63 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.45 |
| ▸ | TOP1 | P11387 | 6/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.43 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | DRD3 | P35462 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901553 | 1.00 | KDM4E (0.63) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL8127450 | 0.89 | KDM4E (0.49) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL9874693 | 0.87 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL9874703 | 0.87 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL9874713 | 0.87 | ALDH1A1 (0.56) | KDM4EALDH1A1HPGDHSD17B10KCNH2 | |
| SCHEMBL8132965 | 0.84 | DRD3 (0.61) | KDM4EALDH1A1HPGDHSD17B10TOP1 | |
| SCHEMBL8901302 | 0.84 | DRD3 (0.61) | KDM4EALDH1A1HPGDHSD17B10TOP1 | |
| SCHEMBL9146255 | 0.83 | KDM4E (0.68) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL10823302 | 0.82 | KDM4E (0.75) | KDM4EALDH1A1HPGDHSD17B10PMP22 | |
| SCHEMBL8699900 | 0.82 | ALDH1A1 (0.71) | KDM4EALDH1A1HPGDHSD17B10PMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0401623-B1 | Process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolinonecarboxylic and -naphthyridinonecarboxylic acids | BAYER AG (DE) | 2000-01-26 | — | — | EP | disclosed |
| US-5648493-A | MULTISTAGE PROCESS BY CONDENSING AN OXO COMPOUND WITH AN AMINO COMPOUND TO PRODUCE AN IMINE THEN REACTING WITH AN OXO QUINOLINE CARBOXYLIC ACID | BAYER AKTIENGESELLSCHAFT (DE) | 1997-07-15 | — | — | US | disclosed |
| US-5061712-A | BACTERICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1991-10-29 | — | — | US | disclosed |
| EP-0401623-A1 | Process for the preparation of 7-(3-amino- and 3-aminomethyl-1-pyrrolidinyl)-3-quinolinonecarboxylic and -naphthyridinonecarboxylic acids | BAYER AG (DE) | 1990-12-12 | — | — | EP | disclosed |