Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 5/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.39 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.39 |
| ▸ | CPS1 | P31327 | 4/20 | 0.38 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6767799 | 0.84 | MAOB (0.62) | MAOBMAOAPARP10PARP14CPS1 | |
| SCHEMBL13741732 | 0.82 | ALDH1A1 (0.45) | MAOBMAOA | |
| SCHEMBL531476 | 0.81 | CPS1 (0.54) | CPS1 | |
| SCHEMBL30820833 | 0.81 | CPS1 (0.54) | CPS1 | |
| SCHEMBL6769847 | 0.81 | MAOB (0.51) | MAOBMAOAPARP10PARP14CPS1 | |
| SCHEMBL8123834 | 0.77 | MAOB (0.45) | MAOBMAOA | |
| SCHEMBL31697317 | 0.77 | MAOB (0.45) | MAOBMAOA | |
| SCHEMBL8124711 | 0.74 | MRGPRX4 (0.46) | MAOB | |
| SCHEMBL2171833 | 0.73 | EGFR (0.43) | MAOBPARP10PARP15 | |
| SCHEMBL4629785 | 0.73 | LMNA (0.43) | PARP10PARP14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663393-B1 | 3-Amino/hydroxy-4- 4-benzoylphenylcarboxylamino/oxy -azepanes and their homologies as protein kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2000-07-05 | — | — | EP | disclosed |
| US-5914406-A | ENZYME INHIBITOR; USEFUL FOR TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMAN-LA ROCHE INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5750706-A | TREATMENT OF INFLAMMATORY SKIN DISORDERS AND ALOPECIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-12 | — | — | US | disclosed |
| US-5583222-A | ANTIINFLAMMATORY AGENTS FOR TREATMENT OF SKIN DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1996-12-10 | — | — | US | disclosed |
| EP-0663393-A1 | Novel 3-amino/hydroxy-4- 4-benzoylphenylcarboxylamino/oxy -azepanes and their homologies as protein kinase inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1995-07-19 | — | — | EP | disclosed |