Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 4/20 | 0.47 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | CCR3 | P51677 | 2/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8131620 | 0.84 | ACHE (0.49) | ACHEBCHESLC6A4HTR1ADRD2 | |
| SCHEMBL8119111 | 0.83 | BCHE (0.48) | ACHEBCHECCR3 | |
| SCHEMBL8124394 | 0.79 | BCHE (0.51) | ACHEBCHEHTR1A | |
| SCHEMBL6214011 | 0.78 | SLC6A4 (0.61) | ACHESLC6A4HTR1ADRD2DRD3 | |
| SCHEMBL8130052 | 0.78 | ACHE (0.50) | ACHEBCHEDRD2 | |
| SCHEMBL8119499 | 0.78 | BCHE (0.46) | ACHEBCHEHTR1ACCR3 | |
| SCHEMBL8124392 | 0.77 | BCHE (0.45) | ACHEBCHECCR3 | |
| SCHEMBL8129045 | 0.76 | BCHE (0.45) | ACHEBCHEDRD2CCR3 | |
| SCHEMBL8129042 | 0.76 | BCHE (0.45) | ACHEBCHEDRD2CCR3 | |
| SCHEMBL8132943 | 0.76 | BCHE (0.49) | ACHEBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610134-B1 | Indole derivatives as 5-HT1-like agonists | ADIR (FR) | 2000-04-05 | — | — | EP | disclosed |
| US-5348968-A | Migraines | ADIR ET COMPAGNIE (FR) | 1994-09-20 | — | — | US | disclosed |
| EP-0610134-A1 | Indole, indazole and benzisoxazole derivatives as 5-HT1-like agonists | ADIR ET COMPAGNIE (FR) | 1994-08-10 | — | — | EP | disclosed |