Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK3 | P27361 | 1/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 7/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.43 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6866955 | 0.83 | ALDH1A1 (0.54) | GRM4HPGDVNN1MAPTKDM4E | |
| SCHEMBL28253118 | 0.83 | S1PR3 (0.46) | S1PR3GRM4HPGDVNN1SLC6A2 | |
| SCHEMBL6869441 | 0.82 | S1PR3 (0.52) | S1PR3S1PR1LMNA | |
| SCHEMBL13527528 | 0.80 | HPGD (0.61) | HPGDSLC6A2SLC6A3MAPTKDM4E | |
| SCHEMBL15938538 | 0.80 | MAPK13 (0.44) | MAPK3S1PR3MAPK13MAPK12MAPK11 | |
| SCHEMBL8139092 | 0.77 | VCAM1 (0.46) | S1PR3GRM4VNN1SLC6A2SLC6A3 | |
| SCHEMBL24494667 | 0.77 | VCAM1 (0.46) | S1PR3GRM4VNN1MAPTMEN1 | |
| SCHEMBL15867032 | 0.77 | VNN1 (0.56) | S1PR3GRM4VNN1MAPTMRGPRX4 | |
| SCHEMBL7491104 | 0.77 | HPGD (0.50) | HPGDVNN1KDM4EALDH1A1LMNA | |
| SCHEMBL13568210 | 0.76 | HPGD (0.45) | HPGDSLC6A2SLC6A3MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0808318-B1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LAB (US) | 2000-06-28 | — | — | EP | disclosed |
| US-5597823-A | TREATING BENIGN PROSTATIC HYPERPLASIA | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| WO-1996022992-A1 | TRICYCLIC SUBSTITUTED HEXAHYDROBENZ[E]ISOINDOLE ALPHA-1 ADRENERGIC ANTAGONISTS | ABBOTT LABORATORIES (US) | 1996-08-01 | — | — | WO | disclosed |