Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 5/20 | 0.38 |
| ▸ | EPAS1 | Q99814 | 5/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.34 |
| ▸ | MAP3K14 | Q99558 | 2/20 | 0.34 |
| ▸ | CDK2 | P24941 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30523681 | 0.85 | CA12 (0.46) | HIF1AEPAS1CA12CA9ALDH1A1 | |
| SCHEMBL506743 | 0.85 | CA12 (0.46) | HIF1AEPAS1CA12CA9ALDH1A1 | |
| SCHEMBL20766474 | 0.74 | ODC1 (0.44) | CA12CA9ALDH1A1HPGDKDM4E | |
| SCHEMBL30065854 | 0.74 | ODC1 (0.44) | CA12CA9ALDH1A1HPGDKDM4E | |
| SCHEMBL6984727 | 0.71 | RAB9A (0.41) | HIF1AEPAS1CA12CA9ALDH1A1 | |
| SCHEMBL9293857 | 0.70 | HIF1A (0.43) | HIF1AEPAS1EP300 | |
| SCHEMBL9206139 | 0.69 | CA12 (0.40) | CA12CA9KDM4EABCB1 | |
| SCHEMBL6980284 | 0.69 | CA12 (0.40) | CA12CA9KDM4EABCB1 | |
| SCHEMBL2012004 | 0.69 | HIF1A (0.46) | HIF1AEPAS1CA12CA9ALDH1A1 | |
| SCHEMBL9042019 | 0.68 | HIF1A (0.44) | HIF1AEPAS1CA12CA9ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1037886-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | Abbott Laboratories (US) | 2000-09-27 | — | — | EP | disclosed |
| WO-1999031088-A1 | TRIAZINE ANGIOGENESIS INHIBITORS | ABBOTT LABORATORIES (US) | 1999-06-24 | — | — | WO | disclosed |