Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.59 |
| ▸ | HTR1A | P08908 | 8/20 | 0.59 |
| ▸ | DRD3 | P35462 | 6/20 | 0.59 |
| ▸ | HTR2A | P28223 | 4/20 | 0.59 |
| ▸ | HTR7 | P34969 | 4/20 | 0.59 |
| ▸ | HTR6 | P50406 | 3/20 | 0.59 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.59 |
| ▸ | DRD4 | P21917 | 3/20 | 0.57 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.56 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.56 |
| ▸ | HTR2B | P41595 | 1/20 | 0.56 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474943 | 0.93 | HTR1A (0.59) | DRD2HTR1AADRA1ADRD4ADRA1D | |
| SCHEMBL8129997 | 0.89 | DRD2 (0.56) | DRD2HTR1ADRD3HTR2AHTR7 | |
| Hydrochloric Acid SCHEMBL8129386 | 0.89 | HTR1A (0.59) | DRD2HTR1ADRD3HTR2AHTR7 | |
| SCHEMBL8136283 | 0.88 | DRD2 (0.57) | DRD2HTR1ADRD3HTR2AHTR7 | |
| SCHEMBL8130173 | 0.82 | DRD2 (0.71) | DRD2HTR1ADRD3HTR2AHTR7 | |
| SCHEMBL6930794 | 0.80 | DRD2 (0.66) | DRD2HTR1ADRD3HTR2AHTR7 | |
| SCHEMBL6930819 | 0.79 | MAPT (0.49) | HTR1A | |
| SCHEMBL11715381 | 0.79 | HTT (0.60) | HTR6 | |
| SCHEMBL7609800 | 0.78 | HTR1A (0.50) | HTR1A | |
| SCHEMBL7732078 | 0.78 | DRD2 (0.50) | DRD2HTR1ADRD3ADRA1AADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526434-B1 | Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists | BOEHRINGER INGELHEIM ITALIA (IT) | 2000-04-19 | — | — | EP | disclosed |
| US-5576318-A | FOR TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1996-11-19 | — | — | US | disclosed |
| WO-1993003016-A1 | BENZIMIDAZOLONE DERIVATIVES AS 5-HT1A AND 5-HT2 ANTAGONISTS | BOEHRINGER INGELHEIM ITALIA S.P.A. (IT) | 1993-02-18 | — | — | WO | disclosed |
| EP-0526434-A1 | Benzimidazolone derivatives as 5-HT1A and 5-HT2 antagonists | BOEHRINGER INGELHEIM ITALIA S.p.A. (IT) | 1993-02-03 | — | — | EP | disclosed |