Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.65 |
| ▸ | MAPT | P10636 | 8/20 | 0.65 |
| ▸ | NPC1 | O15118 | 7/20 | 0.65 |
| ▸ | HPGD | P15428 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | GAA | P10253 | 6/20 | 0.65 |
| ▸ | TP53 | P04637 | 4/20 | 0.65 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.65 |
| ▸ | APP | P05067 | 1/20 | 0.65 |
| ▸ | SNCA | P37840 | 1/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.65 |
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.65 |
| ▸ | POLB | P06746 | 5/20 | 0.60 |
| ▸ | USP2 | O75604 | 3/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8130390 | 0.89 | ALDH1A1 (0.54) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL7652960 | 0.87 | KDM4E (0.61) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL8174405 | 0.87 | KDM4E (0.61) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL412846 | 0.84 | MEN1 (0.74) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL2361964 | 0.82 | ALDH1A1 (0.52) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL7652411 | 0.79 | MMP13 (0.73) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL20445410 | 0.79 | KDM4E (0.68) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL7187637 | 0.79 | ALDH1A1 (0.68) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL26731643 | 0.79 | MEN1 (1.00) | MEN1KMT2AALDH1A1MAPTNPC1 | |
| SCHEMBL8396715 | 0.78 | ALDH1A1 (0.81) | MEN1KMT2AALDH1A1MAPTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054870-A1 | HETEROCYCLIC TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2000-11-29 | — | — | EP | disclosed |
| WO-1999041241-A1 | HETEROCYCLIC TOPOISOMERASE POISONS | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 1999-08-19 | — | — | WO | disclosed |