Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR5 | P51681 | 7/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8132047 | 0.86 | CCR5 (0.56) | CCR5CYP2D6LMNA | |
| SCHEMBL8120303 | 0.84 | CACNA2D1 (0.53) | CCR5CYP2D6TDP1CACNA2D1CACNA1B | |
| SCHEMBL4138903 | 0.83 | CCR5 (0.58) | CCR5CYP2D6LMNA | |
| SCHEMBL4134368 | 0.79 | CCR5 (0.54) | CCR5CYP2D6LMNA | |
| SCHEMBL8132322 | 0.77 | ALDH1A1 (0.48) | CCR5CYP2D6CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL8123193 | 0.76 | CACNA2D1 (0.44) | CCR5CYP2D6TDP1CACNA2D1CACNA1B | |
| SCHEMBL12799041 | 0.76 | CCR5 (0.51) | CCR5CYP2D6LMNA | |
| SCHEMBL13743001 | 0.75 | CCR5 (0.50) | CCR5CYP2D6LMNA | |
| SCHEMBL8134531 | 0.74 | CACNA2D1 (0.42) | CCR5CYP2D6LMNACACNA2D1CACNA1B | |
| SCHEMBL8128926 | 0.74 | CYP2D6 (0.44) | CCR5CYP2D6TDP1CACNA2D1CACNA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0738269-B1 | PIPERIDINE DERIVATIVES WITH PAF ANTAGONIST ACTIVITY | URIACH & CIA SA J (ES) | 2000-04-26 | — | — | EP | disclosed |
| EP-0738269-A1 | NOVEL PIPERIDINE DERIVATIVES WITH PAF ANTAGONIST ACTIVITY | J. URIACH & CIA. S.A. (ES) | 1996-10-23 | — | — | EP | disclosed |
| WO-1996014317-A1 | NOVEL PIPERIDINE DERIVATIVES WITH PAF ANTAGONIST ACTIVITY | J. URIACH & CIA. S.A. (ES) | 1996-05-17 | — | — | WO | disclosed |