Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | SLC10A2 | Q12908 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8884141 | 0.92 | MAPT (0.60) | MAPTKDM4EGAAPOLBALDH1A1 | |
| SCHEMBL8883731 | 0.91 | MAPT (0.59) | MAPTKDM4EGAAPOLBALDH1A1 | |
| SCHEMBL7824433 | 0.91 | KDM4E (0.58) | MAPTKDM4EGAAPOLBALDH1A1 | |
| SCHEMBL8884728 | 0.88 | KDM4E (0.55) | MAPTKDM4EGAAPOLBALDH1A1 | |
| SCHEMBL9044254 | 0.87 | KDM4E (0.54) | MAPTKDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8886500 | 0.87 | GAA (0.52) | MAPTKDM4EGAAPOLBALDH1A1 | |
| SCHEMBL8137949 | 0.87 | KDM4E (0.54) | MAPTKDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL7820772 | 0.85 | GAA (0.50) | MAPTKDM4EGAAPOLBALDH1A1 | |
| SCHEMBL7820569 | 0.84 | KDM4E (0.52) | MAPTKDM4EGAAALDH1A1SMN1; SMN2 | |
| SCHEMBL8121588 | 0.84 | SLC10A2 (0.53) | MAPTKDM4EGAAPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634169-B1 | Quinoline or quinazoline derivatives and their use in the manufacture of a medicament for the treatment of osteoporosis | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-01-05 | — | — | EP | disclosed |
| US-5852039-A | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-22 | — | — | US | disclosed |
| US-5719157-A | OSTEOPOROSIS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-17 | — | — | US | disclosed |
| US-5650410-A | ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-07-22 | — | — | US | disclosed |
| EP-0634169-A1 | Pharmaceutical composition containing quinoline or quinazoline derivatives | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1995-01-18 | — | — | EP | disclosed |